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Integrative Modeling and Visualization of Exosomes

Julia Jimenez, Ludovic Autin, Inmaculada Ibáñez de Cáceres, David S. Goodsell

Abstract


Information from proteomics, microscopy, and structural biology are integrated to create structural models of exosomes, small vesicles released from cells. Three visualization methods are employed and compared: 2D painting of a cross section using traditional media, manual creation of a cross section using the mesoscale 2.5D digital painting software cellPAINT, and generation of a 3D atomic model using the mesoscale modeling program cellPACK.


Keywords


Exosome, integrative structural biology, molecular visualization, non-photorealistic rendering, protein structure

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DOI: https://doi.org/10.5210/jbc.v43i2.10331



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